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Reversing aging Introduction
Reversing aging is an ongoing quest for longevity that researchers are exploring through various methods.Various factors, including genetics, environment, and lifestyle, influence the complex process of reversing aging. In recent years, researchers have been investigating the use of drugs to target aging, rather than individual diseases.
Metformin and its effects on Reversing aging
Dr. Nir Barzilai, a professor of medicine and genetics at Albert Einstein College of Medicine, takes metformin off label to target aging. Researchers have discovered that metformin, a drug commonly used to treat diabetes, has remarkable effects on the aging process. Studies have shown that people on metformin have lower rates of almost every kind of cancer, delay cognitive decline, and have lower mortality rates than people who aren’t on the drug.
Metformin not only treats diabetes, but it also seems to delay and compress the years of chronic illness associated with the final stage of life and extend the “healthspan.” Scientists believe that metformin works by lowering the level of glucose in the blood, which research has linked to numerous age-related diseases.
Senolytics and their effects on aging
Researchers in the longevity field are also exploring other medications, including senolytics, which clear out toxic, old, dysfunctional cells called senescent cells. These cells stick around and give off toxic substances that can harm the healthy cells around them, especially around the sites where chronic diseases develop, like macular degeneration.
The end goal of researchers is to make a drug that would clear out all senescent cells, not just the ones behind a certain disease, to target aging rather than just individual diseases. This approach could potentially delay or even prevent many age-related diseases.
Epigenetic changes and their effects on aging
from a lifetime of environmental, behavioral, and exposure factors that can cause disease or signs and symptoms of old age. Think of them as scratches on a record: you can still hear the music, but it’s distorted.
Researchers are studying ways to reverse or slow down these epigenetic changes to prolong life. One approach is to use drugs that modify epigenetic markers, which can potentially reverse some of the changes that occur during aging.
In conclusion, the search for ways to prolong life is ongoing, and researchers are exploring different methods to target aging. Metformin, senolytics, and epigenetic changes are just a few of the areas being studied. It is exciting to think that we may one day have a drug that can target aging, delay or prevent age-related diseases, and extend our healthspan. However, more research is needed before these drugs become widely available.